If you are looking for a particular reference, you may search for it in a remote database directly from EndNote. This is particularly easy when the database is publicly accessible, for example: PubMed, so that you do not need to authenticate your access. However, I would not recommend using this search function if you are performing a topic search, which should be conducted in a relevant database.
To search PubMed from EndNote:
Note: The online search feature in EndNote 20 has been much improved. Users are recommended to use EndNote 20 for this feature.
If what you want to search for is a book reference, you may search for it in the Library of Congress (LC) online catalog. To search the LC catalog from EndNote, here are the steps:
Note: The online search feature in EndNote 20 has been much improved. Users are recommended to use EndNote 20 for this feature.