If you are looking for a particular reference, you may search for it in a remote databases directly from EndNote. This is particularly easy when the database is publicly accessible, so that you do not need to authenticate your access. I would not recommend using this search function if you are doing a topic search.
To search PubMed from EndNote:
If the reference you want to search for is a book reference and is related to health sciences, you may search for it in the NLM online catalog. To search NLM catalog from EndNote, here are the steps:
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